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Molecular Biology for the Vitamin D Receptor

Molecular biology of the calciferol receptor (VDR) is a key factor in most processes which can be important for agentur winter impressum general homeostasis. VDRs are located in a variety of cellular material, including monocytes, dendritic cells, macrophages, neutrophils, keratinocytes, and epithelial cells.

The vitamin D receptor is a nuclear receptor that is stimulated by the vitamin D hormone. This can be a receptor that forms a heterodimer with the retinoid X radio. The holding of the vitamin D complex with the RXR ends in the activation of many intracellular signaling pathways. These kinds of pathways produce immediate answers independent of the transcriptional response of target genetics.

VDRs are thought to mediate the effects of vitamin D on bone tissue maintenance. This is maintained the relationship between cuboid density and VDR radio alleles in individuals. In addition , a number of VDR focus on genes have been completely identified, which include calcium-binding healthy proteins, calbindin D-9k and 25-hydroxyvitamin D3 24-hydroxylase.

Many studies contain investigated the expression of VDR in various flesh. For instance, confocal microscopy has shown VDR indivisible staining in human bande cells. In addition , VDR has been diagnosed in bright white matter oligodendrocytes. These conclusions have generated the hypothesis that calcium-dependent platelet service may be governed by speedy non-genomic effects of VDR in mitochondria.

In addition to vitamin D, VDRs have been suggested as a factor in dangerous calcium homeostasis in the intestinal tract. Nevertheless , the exact device is not yet known. Various elements, including environmental exposures and genetic elements, may control VDR reflection.

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